Epigenetic Methylation Station

Your source for information, protocols, and bioinformatics about epigenetics and DNA methylation.

High Performance Capillary Electrophoresis

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This method allows for the accurate quantification of the total amount of 5-methylcytosines in the entire genome. High-performance Capillary Electrophoresis (HPCE) allows for separation of molecules, similar to the HPLC, but uses narrow-bore fused-silica capillary membranes to separate complex mixtures. Molecules are separated through the molecules size, structure, as well as charge and hydrophobic potential by electric fields.

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